Interstitial Cells of Cajal and Neural Structures in the Human Fetal Appendix
نویسندگان
چکیده
منابع مشابه
Interstitial cells of Cajal in the human fetal small bowel as shown by c-kit immunohistochemistry.
BACKGROUND Interstitial cells of Cajal (ICCs) express the tyrosine kinase receptor c-kit, which is required for their development and spontaneous pacemaker activity in the bowel. From murine models it has been proposed that ICCs do not develop until after birth, but more recent findings indicate that c-kit is expressed early in the embryonic period. The temporal development of ICCs in the human...
متن کاملPrecursor and interstitial Cajal cells in the human embryo liver.
Interstitial Cajal Cells (ICCs) were only proven in human adult hepatic tissue. The immune phenotypes of various cell types in the human embryonic liver (HEL) are scarcely described. It was hypothesized that in HEL ICCs are present and distinctive to the precursor/progenitor cells populations. It was aimed and performed a qualitative study of HEL by use of antibodies against CD117/c-kit, CD31, ...
متن کاملIdentification of interstitial cells of Cajal in the human rectum.
It is postulated that the electric waves of the gut are generated by interstitial cells of Cajal (ICC). We hypothesized the presence of ICC in the rectum as initiating the rectal electric activity. The current study investigated this hypothesis. Two rectal specimens were taken from healthy areas of excised rectum of 22 rectal cancer patients (age 44.6+/-.2 SD years, 12 men, 10 women). The study...
متن کاملInterstitial cells of Cajal in the urethra
The smooth muscle layer of the urethra generates spontaneous myogenic tone that is thought to make a major contribution to urinary continence. The mechanisms underlying generation of tone remain unclear, however recent studies from our laboratory highlighted a role for a specialised population of pacemaker cells which we originally referred to as interstitial cells (IC) and now term ICC. Urethr...
متن کاملPerivascular Interstitial Cells of Cajal in Human Colon
BACKGROUND & AIMS Interstitial cells of Cajal (ICC) closely associate with nerves and smooth muscles to modulate gut motility. In the ICC microenvironment, although the circulating hormones/factors have been shown to influence ICC activities, the association between ICC and microvessels in the gut wall has not been described. We applied three-dimensional (3D) vascular histology with c-kit stain...
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ژورنال
عنوان ژورنال: Journal of Neurogastroenterology and Motility
سال: 2021
ISSN: 2093-0879,2093-0887
DOI: 10.5056/jnm20100